A review of the pharmacological activities of honey

Authors

  • Okiemute R. Johnson-Ajinwo Department of Pharmaceutical/Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria
  • Chiamaka A. Obi Department of Pharmaceutical/Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria

Keywords:

Honey, pharmacological activities

Abstract

Background: Since ancient times, Honey has been highly prized and widely used by humans for both nourishment
and medicinal purposes. The sweet substance known as honey is mostly made by honey bees from the nectar and parts
of plants. Because of its amazing therapeutic abilities due to its Antioxidant, Antibacterial, Anti-inflammatory,
Antiproliferative, Anticancer, and Antimetastatic properties, honey is and has been used for a wide range of illnesses
in traditional medical systems and in majority of ancient cultures and religion for millennia.
Methods: An online search of relevant databases for the pharmacological activities of honey was undertaken.
Websites such as PubMed, Google Scholar, Web of Science were utilized. The characteristics and the types of honey
were considered in this review. Also, the value and significance of honey was discussed.
Results: The review uncovered numerous aspects of honey such as- Description/Composition of honey, History of
honey, Religious significance of honey, Income analysis of honey production, Types of honey, Physical properties of
honey, Thermal characteristics of honey, Shelf life of honey, Preservative properties of honey with greater emphasis
on the Therapeutic properties of honey.
Conclusion: Numerous modern scientific literature point to the potential benefits of using honey in the management
of wounds, diabetes, cancer, diarrhea, urinary tract infections, infertility, arthritis, eye problems, asthma, and a host
of other conditions including neurological, gastrointestinal, respiratory, and cardiovascular disorders. The two main
class of bioactive compounds found in honey are flavonoids and polyphenols, both of which have antioxidant
properties.

References

Elbanna K, Attalla K, Elbadry M, Abdeltawab A, Gamal-Eldin H, Ramadan MF. Impact of floral sources and processing on the antimicrobial activities of different unifloral honeys. Asian Pac J Trop Dis. 2014 Jun;4(3):194–200. doi: 10.1016/S2222-1808(14)60504-1. PMCID: PMC4032034.

Buba, F., Gidado, A. and Shugaba, A. (2013). Analysis of Biochemical composition of Honey Samples.

Satarupa, R., and G. Subha. "Physical, chemical and antioxidant properties of honey: A review." Asian J. Chem. Pharm. Res 2 (2014): 96-99.

Adenekan, M.O., Amusa, N.A, Lawal, O.A & Okpeze, V.E. (2010). “Physico-Chemical and Microbiological Properties of Honey Samples Obtained from Ibadan,” Journal of Microbiology and Antimicrobials, Vol. 2, No. 8, 2010, pp. 100-104.

Chua LS, Abdul-Rahaman N-L, Sarmidi MR, Aziz R (2012) Multi-element composition and physical properties of honey samples from Malaysia. Food Chem 135:880–887.

James, Olusola & Mesubi, M & Usman, Lamidi & Yeye, S & Oluseyi, Ajanaku & Olurotimi, Ogunniran & Ajani, Olayinka & Siyanbola, Tolutope. (2009). Physical characterisation of some honey samples from North-Central Nigeria. International Journal of Physical Sciences. 4.

Johnson RK, Appel LJ, Brands M, Howard BV, Lefevre M, Lustig RH. American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism and the Council on Epidemiology and Prevention. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2009 Sep 15;120(11):1011-20.

Nast, Condé (14 February 2013). "The Origin of the Word 'Honey'". Bon Appétit. Retrieved 24 October 2023.

Rachel Hajar (2008). Selin, Helaine (ed.). Encyclopedia of the History of Science, Technology and Medicine in Non-Western Cultures. Springer. p. 89.

Franke, G. Potsherds in Time—the Pottery of the Nigerian Nok Culture and its Chronology (Verlag Dr. Hut, published online 12/2016).

Breunig P, Rupp N. An outline of recent studies on the Nigerian Nok Culture. J. Afr. Archaeol. 2016; 14:237–255.

Crane, E. The World History of Beekeeping and Honey Hunting (Routledge, 1999).

Pager H. Rock paintings in Southern Africa showing bees and honey hunting. Bee World. 1973; 54:61–68. doi: 10.1080/0005772X.1973.11097456.

Gills, R.A. 2007. Apiculture as an Aspect of Nigeria's Economy.

Henrichs, Albert (1 April 1980). Harvard Studies in Classical Philology. Harvard University Press. ISBN 9780674379305

Pećanac M, Janjić Z, Komarcević A, Pajić M, Dobanovacki D, Misković SS (2013). "Burns treatment in ancient times". Med Pregl. 66 (5–6): 263–7. doi:10.1016/s0264-410x(02)00603-5. PMID 23888738.

Bramen L (n.d.) (2009). Why honey is eaten for Rosh Hashanah, and other burning questions | Arts & Culture | Smithsonian Magazine. Smithsonian Magazine.

Yusuf 'Ali, 'Abdullah. An Nahl, Al-Quran Chapter 16 (The Bee) quoted from "The Holy Qur'an: Original Arabic Text with English Translation & Selected Commentaries". Saba Islamic Media. Archived from the original on 26 February 2013. Retrieved 20 May 2013.

Okpokiri, C., Nwachukwu, I.N., & Onwusiribe, C.N. (2015). Determinants and profitability of honey production in Ikwuano Local Government Area, Abia state, Nigeria.

Babatunde, R.O; Olorunsanya, E.O; Omotesho, O.A. and Alao, B.I. (2007): Economics of Honey Production in Nigeria: Implication for Poverty Reduction and Rural Development. Global Approaches to Extension Practice: A Journal of Agricultural Extension, 3(2): 23-29.

Manyi-Loh, C.E.; Ndip, R.N.; Clarke, A.M. Volatile Compounds in Honey: A Review on Their Involvement in Aroma, Botanical Origin Determination and Potential Biomedical Activities. Int. J. Mol. Sci. 2011, 12, 9514-9532. https://doi.org/10.3390/ijms12129514.

"Extracted Honey Grading Manual" (PDF). U.S. Agricultural Marketing Service (AMS). Retrieved 17 May 2019.

"Honey Varietals". National Honey Board. 2018. Retrieved 25 June 2018. “The color, flavor and even aroma of honey differ, depending on the nectar of flowers visited by the bees that made it. There are more than 300 unique types of honey available in the United States alone, each originating from a different floral source”.

Flottum, Kim (2010). The Backyard Beekeeper: An Absolute Beginner's Guide to Keeping Bees in Your Yard and Garden. Quarry Books. pp. 170–. ISBN 978-1-61673-860-0. Retrieved 5 January 2016.

"Definition of Honey and Honey Products" (PDF). National Honey Board. 15 June 1996. Archived from the original (PDF) on 3 December 2007.

Chaven, Suchart (1 November 2013). Food Safety Management: Chapter 11. Honey, Confectionery and Bakery Products. Elsevier Inc. Chapters. ISBN 9780128056509.

Damerow, Gail (2011). The Backyard Homestead Guide to Raising Farm Animals: Choose the Best Breeds for Small-Space Farming, Produce Your Own Grass-Fed Meat, Gather Fresh Eggs, Collect Fresh Milk, Make Your Own Cheese, Keep Chickens, Turkeys, Ducks, Rabbits, Goats, Sheep, Pigs, Cattle, & Bees. Storey Publishing, LLC. pp. 167–. ISBN 978-1-60342-697-8. Retrieved 5 January 2016.

Subramanian, R.; Hebbar, H. Umesh; Rastogi, N. K. (2007). "Processing of Honey: A Review". International Journal of Food Properties. 10: 127–143. doi:10.1080/10942910600981708. S2CID 98158536.

Sharma, Rajeev (2005). Improve your Health! with Honey. Diamond Pocket Books. pp. 33–. ISBN 978-81-288-0920-0. Retrieved 5 January 2016.

Krell, R. (1996). Value-added products from beekeeping. Food and Agriculture Organization of the United Nations. p. 5. ISBN 978-92-5-103819-2. Retrieved 5 January 2016.

Reinhardt, J.F., 1952. Some responses of honey bees to alfalfa flowers. The American Naturalist, 86(830), pp.257-275.

Biacs, P., Aubrecht, E., Léder, I. and Lajos, J., 2002. Buckwheat. Pseudocereals and Less Common Cereals, pp.123-151.

Tan, S.T.; Holland, P.T.; Wilkins, A.L.; Molan, P.C. Extractives from New Zealand honeys White clover, manuka and kanuka unifloral honeys. J. Agric. Food Chem. 1988, 36, 453–460.

Ellegood, J. A. and Fischer,L. (1941)1400093, English, Journal article, 5, Food Research, (559–561), Composition of fireweed honey.

Israili, Zafar H. MS, PhD. Antimicrobial Properties of Honey. American Journal of Therapeutics 21(4):p 304-323, July/August 2014. | DOI: 10.1097/MJT.0b013e318293b09b.

Alvarez-Suarez JM, Tulipani S, Díaz D, Estevez Y, Romandini S, Giampieri F, Damiani E, Astolfi P, Bompadre S, Battino M. (2010). Antioxidant and antimicrobial capacity of several monofloral Cuban honeys and their correlation with color, polyphenol content and other chemical compounds. Food ChemToxicol., 48(8-9):2490-9.

Finola, M.S., Lasagno, M.C. and Marioli, J.M., 2007. Microbiological and chemical characterization of honeys from central Argentina. Food chemistry, 100(4), pp.1649-1653.

Scripca, L. and Amariei, S. Research on honey crystallization Revista de Chimie, 10 (2018), pp. 2953-2957.

Root, A. I.; Root, E. R. (2005). The ABC and Xyz of Bee Culture. Kessinger Publishing. ISBN 978-1-4179-2427-1. Retrieved 5 January 2016.

Tomasik, Piotr (2004) Chemical and functional properties of food saccharides, CRC Press, p. 74, ISBN 0-8493-1486-0.

Abu-Jdayil, B., Ghzawi, A.A.M., Al-Malah, K.I.M., and Zaitoun, S. 2002. Heat effect on rheology of light- and dark-colored honey. Journal of Food Engineering 51: 33–38.

Yanniotis, S., Skaltsi, S., and Karaburnioti, S. 2006. Effect of moisture content on the viscosity of honey at different temperatures. Journal of Food Engineering 72: 4372–4377.

Munro, J.A. 1943. The viscosity and thixotropy of honey. Journal of Economic Entomology 36: 769–777.

Iglesias, A., Pascoal, A., Choupina, A.B., Carvalho, C.A., Feás, X. and Estevinho, L.M., 2014. Developments in the fermentation process and quality improvement strategies for mead production. Molecules, 19(8), pp.12577-12590.

Hans-Dieter Belitz, Werner Grosch, Peter Schieberle Food chemistry Springer Verlag, Berlin-Heidelberg 2004 p. 884 ISBN 3-540-69933-3.

Zdzisław E. Sikorski Chemical and functional properties of food components CRC Press 2007 p. 121 ISBN 0-8493-9675-1.

Bogdanov, Stefan (2009). "Physical Properties of Honey" (PDF). Archived from the original (PDF) on 20 September 2009.

Colangelo, Harmony (3 March 2023). "The World's Oldest Jar Of Honey Is From 3500 BC"

Geiling, Natasha (22 August 2013). "The Science Behind Honey's Eternal Shelf Life". Smithsonian. Retrieved 9 September 2019.

Snowdon JA, Cliver DO. Microorganisms in honey. Int J Food Microbiol. 1996 Aug;31(1-3):1-26. doi: 10.1016/0168-1605(96)00970-1. PMID: 8880294.

Molan, Peter. (2015). The Antibacterial Activity of Honey. Bee World. 73. 10.1080/0005772X.1992.11099109.

Moreira, R.F., De Maria, C.A., Pietroluongo, M. and Trugo, L.C., 2010. Chemical changes in the volatile fractions of Brazilian honeys during storage under tropical conditions. Food Chemistry, 121(3), pp.697-704.

George E. Marvin, Further Observations on the Deterioration and Spoilage of Honey in Storage, Journal of Economic Entomology, Volume 23, Issue 2, 1 April 1930, Pages 431–438, https://doi.org/10.1093/jee/23.2.431.

Gleiter, R. A., H. Horn, H. and Isengard H. D. Influence of type and state of crystallisation on the water activity of honey, Food Chemistry,Volume 96, Issue 3, 2006, Pages 441.

Aline Meda, Charles Euloge Lamien, Jeanne Millogo, Marco Romito, Odile Germaine Nacoulma, Therapeutic uses of honey and honeybee larvae in central Burkina Faso, Journal of Ethnopharmacology, Volume 95, Issue 1, 2004, Pages 103-107.

Al-Qassemi, Rasha, Robinson, R.K. (2003). Some special nutritional properties of honey – a brief review. Nutrition & Food Science. 33. 254-260. 10.1108/00346650310507073.

Abeshu MA, Geleta B (2016) Medicinal Uses of Honey. Biol Med (Aligarh) 8: 279. doi:10.4172/0974-8369.1000276.

Saba, Z. H., Suzana, M., & Anum, M. Y. (2013). Honey: Food or medicine. Med. Health,8(1), 3–18.

Khoo, YT., Halim, A.S., Singh, KK.B. et al. Wound contraction effects and antibacterial properties of Tualang honey on full-thickness burn wounds in rats in comparison to hydrofibre. BMC Complement Altern Med 10, 48 (2010).

Ajibola, Abdulwahid; Chamunorwa, Joseph; Erlwanger, Kennedy. (2012). Nutraceutical values of natural honey and its contribution to human health and wealth. Nutrition & metabolism. 9. 61. 10.1186/1743-7075-9-61.

Bahrami M., Ataie-Jafari A., Hosseini S., Foruzanfar M. H., Rahmani M., Pajouhi M. Effects of natural honey consumption in diabetic patients: an 8-week randomized clinical trial. International Journal of Food Science and Nutrition. 2009;60(7):618–626. doi: 10.3109/09637480801990389.

Abdelhafiz, Ahmed & Muhamad, Jehan. (2008). Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 101. 146-9. 10.1016/j.ijgo.2007.11.012.

Abd Rashid N, Mohammed SNF, Syed Abd Halim SA, Ghafar NA, Abdul Jalil NA. Therapeutic Potential of Honey and Propolis on Ocular Disease. Pharmaceuticals (Basel). 2022 Nov 17; 15(11):1419. doi: 10.3390/ph15111419. PMID: 36422549; PMCID: PMC9696375.

Hashim, K.-N.; Chin, K.-Y.; Ahmad, F. The Mechanism of Honey in Reversing Metabolic Syndrome. Molecules 2021, 26, 808. https://doi.org/10.3390/molecules26040808

Burlando, B.; Cornara, L. Honey in dermatology and skin care: A review. J. Cosmet. Dermatol. 2013, 12, 306–313.

Goldman Ran. D. Honey for treatment of cough in children. Canadian Family Physician Dec 2014, 60 (12) 1107-1110

Bennett, Eric MD; Daly, Sarah DO, FAAFP. Is honey better than dextromethorphan at decreasing acute cough in children? Evidence-Based Practice 24(3):p 40-41, March 2021. | DOI: 10.1097/EBP.0000000000000453.

Dustmann, J.H., 1979. Antibacterial effect of honey. Apiacta, 14(1), pp.7-11.

Saikaly, S.K., Khachemoune, A. Honey and Wound Healing: An Update. Am J Clin Dermatol 18, 237–251 (2017).

Olaitan, P.B., Adeleke, O.E., and Ola, I.O. 2007. Honey: A reservoir for microorganisms and an inhibitory agent for microbes. African Health Sciences 7: 159–165.

Temaru E., Shimura S., Amano K., Karasawa T. Antibacterial activity of honey from stingless honeybees (Hymenoptera; Apidae; Meliponinae) Pol. J. Microbiol. 2007;56(4):281.

Lurlina MO, Fritz R (2005). Characterization of microorganisms in Argentinean honeys from different sources. Int. J. Food Microbiol., 105: 297- 304.

Molan P.C. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol. 2001; 2(1):13-9. doi: 10.2165/00128071-200102010-00003. PMID: 11702616.

Wu D, Cederbaum AI. Alcohol, oxidative stress, and free radical damage. Alcohol Res Health. 2003; 27(4):277-84. PMID: 15540798; PMCID: PMC6668865.

Küçük et al., Biological activities and chemical composition of three honeys of different types from Anatolia, Food Chemistry, Volume 100, Issue 2 2007, Pages 526-534, ISSN 0308-8146.

Henriques, A., Jackson, S., Cooper, R. and Burton, N. (2006). Free radical production and quenching in honeys with wound healing potential. Journal of Antimicrobial Chemotherapy, 58: 773-777.

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Published

2024-05-23

How to Cite

Johnson-Ajinwo, O. R., & Obi, C. A. (2024). A review of the pharmacological activities of honey. Journal of Drug Discovery and Research, 3(1), 14–31. Retrieved from https://ddrg.net/index.php/ddrg/article/view/46