Evaluation of inhibitory Effect of Solenostemon monostachyus on alpha amylase and alpha glucosidase enzymes of rats


  • Jude E. Okokon Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
  • Martins O. Anagboso Department of Microbiology, Madonna University Nigeria, Elele Campus, Rivers State, Nigeria.
  • Emmanuel I. Etim Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
  • Lynda O. Asor Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University Nigeria, Elele Campus, Rivers State, Nigeria.


diabetes, alpha glucosidase, alpha amylase, Solenostemon monostachyus


Background: Solenostemon monostachyus (P. Beauv.) Brig. (Lamiaceae) a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo.

Methods: The leaf extract (75, 150, 225 mg/kg) of Solenostemon monostachyus were investigated in vivo for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug.

Results: The leaf extract caused significant (p<0.05) and non-dose-dependent reduction in blood glucose levels of treated rats with the various substrates used.

Conclusion: The results suggest that the leaf extract of Solenostemon monostachyus have the potentials to inhibit alpha amylase and glucosidase in rats.


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How to Cite

Okokon, J. E., Anagboso, M. O., Etim, E. I., & Asor, L. O. (2023). Evaluation of inhibitory Effect of Solenostemon monostachyus on alpha amylase and alpha glucosidase enzymes of rats. Journal of Drug Discovery and Research, 1(2), 1–7. Retrieved from https://ddrg.net/index.php/ddrg/article/view/22