Evaluation of inhibitory Effect of Solenostemon monostachyus on alpha amylase and alpha glucosidase enzymes of rats

Jude E. Okokon; Martins O. Anagboso; Emmanuel I. Etim; Lynda O. Asor

Authors

Jude E. Okokon Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
Martins O. Anagboso Department of Microbiology, Madonna University Nigeria, Elele Campus, Rivers State, Nigeria.
Emmanuel I. Etim Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
Lynda O. Asor Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University Nigeria, Elele Campus, Rivers State, Nigeria.

Keywords:

diabetes, alpha glucosidase, alpha amylase, Solenostemon monostachyus

Abstract

Background: Solenostemon monostachyus (P. Beauv.) Brig. (Lamiaceae) a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo.

Methods: The leaf extract (75, 150, 225 mg/kg) of Solenostemon monostachyus were investigated in vivo for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug.

Results: The leaf extract caused significant (p<0.05) and non-dose-dependent reduction in blood glucose levels of treated rats with the various substrates used.

Conclusion: The results suggest that the leaf extract of Solenostemon monostachyus have the potentials to inhibit alpha amylase and glucosidase in rats.

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